In early drug development, Synelvia proposes the following services:

Pre-clinical studies in models of interest

Evaluation of early PK / distribution in tissues / elimination using unlabelled compounds or stable isotope labelled compounds (2H or 13C):

  • Early PK in mice / rat / rabbit
  • Distribution study: assay of parent compound in liver / brain / kidneys / fat
  • Early PK studies in single catheterized rats / double catheterized rats

PK/PD relations in pre-clinical species:

  • Early PK/PD with telemetry implanted + catheterized rats
  • Early PK/PD with circulating surrogate biomarkers
  • Non-invasive sampling techniques for skin / fur surface lipids collection

Lipidomics assessment for qualitative & quantitative efficacy evaluation of lipid surrogate markers in biological samples

  • Fatty acids exploration in blood / tissues / skin / fur / cell cultures & supernatants
  • Neutral lipids in blood / tissues / skin / fur / cell cultures & supernatants
  • Eicosanoids / inflammation markers in blood / tissues / skin / cell cultures & supernatants
  • Phospholipids / Ceramides in tissues / skin / cell cultures & supernatants

Evaluation of oxidative stress and inflammatory in biological samples / side-effects or efficacy POC in early development

  • MDA/HNE in micro-samples of tissues / culture cells & supernatants
  • 8-iso-PGF2╬▒ / 8-OHdG in urine samples / culture cells & supernatants
  • NAD+/NADH in tissues / culture cells & supernatants
  • Glycated compounds: HbA1c / AGEs in blood / target tissues like cornea / lens / tendons / dermis
  • Antioxidative vitamins C & E analysis in tissues / culture cells & supernatants
  • Mineral analysis of antioxydative minerals in tissues / culture cells & supernatants

Routine automated analysis of various biomarkers in biological samples / side-effects or efficacy POC in early development

  • Proteins / enzymes
  • Other biomarkers

Development & validation of analytical methods:

  • Innovative approach for assay developments of protein based biomarkers (SPR / Biacore┬«)
  • Optimisation of methods to specific biological matrices
  • Sensitivity improvement of bioanalytical methods
  • Precision / accuracy evaluation of methods
  • Pre-analytical requirements / stability in biological matrices
  • Quality control of analysis

Statistical evaluation of data / Interpretation of results

  • Statistical analysis: Analysis of variance / co-variance, ACP, PLS
  • Graphical / global radar explicative representations

Scientific support to product effects/ Help in decision making

Please inquire for more detailed informations in the field of early drug development.